Saralasin acetate(34273-10-4 free base)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Saralasinacetate 是一种非选择性血管紧张素 II 拮抗剂。

Saralasin acetate is a Non-selective angiotensin II antagonist.

Saralasin acetate hydrate (1 nM, 48 or 72 h) inhibits cell growth in 3T3 and SV3T3 cells.Saralasin acetate hydrate (5 μM, 2h) restores Ito, fast (Fast-Inactivating Transient Outward K+ Current in Mouse Ventricle) and I K, slow (Slow-Inactivating Transient Outward K+ Current in Mouse Ventricl) to control levels in myocytes.Saralasin acetate hydrate (0.1-10 nM, 40 min) inhibits binding of FITC-Ang II to rat liver membrane preparation (used as the source of angiotensin receptors) with a Ki value of 0.32 nM for 74% of the binding sites and 2.7 nM for the remaining binding sites.Saralasin acetate hydrate (1 μM, perfused rat ovary in vitro) inhibits the ovulation rate versus control and reduces prostaglandin E2 and 6-keto-prostaglandin F1α levels. Cell Proliferation Assay Cell Line:3T3 and SV3T3 cells Concentration:1 nM Incubation Time:48 h, 72 h Result:Inhibited cell growth in 3T3 and SV3T3 cells and caused an increase of cellular renin concentration.

Saralasin acetate hydrate (intravenous injection, 5-50μg/kg, a single dose) ameliorates the oxidative stress and tissue injury in cerulein-induced pancreatitis.Saralasin acetate hydrate (subcutaneous injection, 10 and 30 mg/kg, a single dose) increases serum renin activity (SRA) in normal, conscious rats, without markedly altering blood pressure or heart rate. Animal Model:Cerulein-induced acute pancreatitis rats modelDosage:5, 10, 20, and 50 μg/kg, a single dose.Administration:Intravenous injection Result:Restored the pancreatic morphological characteristics to the control level.Reduced pancreatic injury and suppressed the glutathione depletion induced by cerulean.Animal Model:Male Sprague-Dawley rats Dosage:10 and 30 mg/kg, a single dose.Administration:Subcutaneous injection Result:Stimulated renin release without altering blood pressure or heart rate at the time of measuring serum renin levels 20 minutes after injection.

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Endocrinology/Hormones

RAAS

angiotensin II receptor

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39698-78-7

990.11

C44H71N13O13

>98% (HPLC)

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CC(C)[C@@H](C(N[C@@H](Cc1cnc[nH]1)C(N(CCC1)[C@@H]1C(N[C@@H](C)C(O)=O)=O)=O)=O)NC([C@H](Cc(cc1)ccc1O)NC([C@H](C(C)C)NC([C@H](CCCN=C(N)N)NC(CNC)=O)=O)=O)=O.CC(O)=O.O

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(-20℃)

With Ice Pack

≥ 2 years